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So how do you figure out whether you have the SUOX SNP or not?

So persons ++ with the Fut2 genes - my friend is ++ for all 3 FUT2 SNPS may have high B12 in blood or plasma but because of gut issues are unable to absorb - Do I have that right?

So persons ++ with the Fut2 genes - my friend is ++ for all 3 FUT2 SNPS may have high B12 in blood or plasma but because of gut issues are unable to absorb - Do I have that right?

i use pure encapsulations drops under my tongue; methyl. if you switch try it at low dose say 6 drops for a month then get retested is my suggestion. google hi b2. it is an indicator of other diseases so i would watch it. looks like i answer this a while back. i have now added iodine to support my thyroid. whoever asked, yes, lithium orotate potentiates b12 so if you are taking it, try stopping that, too. yasko speaks of how it makes b12 stronger or you can just google it.

as for multivitamins, stay away from them. as much as possible, except for some bs, like b minus if you are mthfr, take SINGLE supps. My psych taught me this. it is the only way to tell if something is putting you out of wack and changing it. yes, it is more expensive. not surprised a "multi" in any form would make you sick. the ratios may be all wrong. get on single elements.

I found this article that describes the role of lithium:
http://www.jpands.org/vol20no4/marshall.pdf

Also, from what I have read, the orotate form is often chosen for its bioavailability and tolerability, but I have also seen aspartate and citrate mentioned.

Can anyone cite the source for lithium orotate helping b12 absorption? Also, do other forms work since they all contain various amounts of elemental lithium or is the orotate form somehow superior for B12 absorption? thx!

I just discovered this PubMed article that finally explains why serum B12 can be so high even when a patient is B12 deficient. This is gold for all of us "false normals" out there. I'm going to print this out and give it to my GP.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827408/

You might want to consider taking lithium orotate. If you may have high amounts of B12 then you may not be getting the B12 into the cell. Lithium orotate shuttles it into the cell.

@@RO2285 - Me too! The hydroxycobalamin is working great. My naturopathic doctor has me taking 2,000 mcg of sublingual hydroxycobalamin every other day. On alternating days, I take a smaller dose of methylcobalamin as part of a B complex. My headaches, which were weekly, are completely gone, and my energy is up. My doc explained to me that taking high doses of methylcobalamin (which I was doing) was like trying to put a 2016 engine into a 1970s car. The engine may work great but the old car can't keep up with that fancy new engine. She said the hydroxycobalamin would enable the rest of my body to adjust and catch up before possibly reintroducing more methylcobalamin later.

I am the same, cant use or convert b12. Now i am using Hydroxocobalamin and works awesome!

I am homozygous for FUT2 as well and have very high B12 serum levels. The serum test is useless, as it doesn't differentaite between active and inactive B12: my MMA urinary test (as part of Genova's ONE test) was very high for MMA and I was starting to have signs of severe deficiency. I am not convinced that oral B12 preparations work that well, as only a fraction is absorbed, even if you are taking methylcobalamin. I use the topical B12 oils from Australia. By the way, for many people, including me, adenosylcobalamin can be as important as methylcobalamin and the two do have slightly different functions. The oil I use contains both forms.

@IE4441 - There's a thread on Pheonix Rising that indicates homocysteine and MMA tests may not always be reliable when determining adequate levels of B12: http://forums.phoenixrising.me/index.php?threads/low-homocysteine-and-b12-deficiency.5562/

Thanks @@NI1578
I will look into the phage idea. I will have time as I am going to start the "gut phase" of my recovery with a Humaworm parasite cleanse. Let's get the big guys out of the way first. Might be a pipe-dream - with 25 different herbs there is little likelihood that I won't react to at least one of them. Out to supper last night and I forgot to mention Worchestershire Sause to the waitress. Broke out in hives.
Should have done the parasite cleanse decades ago. I drank water out of the Nile in my reckless youth.

We really can't tell the difference b/w B12 made by bacteria in your gut(not bioavailable) and b12 that you absorb from your diet( or supplemented) with standard lab test. So look at homocysteine and urinary MMA. If they are elevated then supplement!

@@DU4948 and @IE4441 I have not been diagnosed with SIBO specifically but blood tests show I have dysbiosis (more bad gut bacteria than good) despite taking daily probiotics the last couple of years. My naturopathic doctor now has me taking Designs for Health ProbioPhage DF, which incorporates probiotics and phage therapy. I've been on it for about a month and feel ten times better! All my vitamins seem to be absorbing better too, and I'm finally able to tolerate oral magnesium, which would always cause me gut problems. I had never heard of phage therapy before but learned that phages are highly specific viruses that invade and eliminate bacteria. The combo of phage therapy and probiotics eliminates bad bacteria and replaces it with good bacteria. (Phage therapy has been used for decades in Eastern European countries but was never picked up in the West apparently because antibiotics were more profitable. Research has continued steadily throughout the decades in Europe and it's now making its way back to the West.) Another piece to add to the B12 absorption puzzle!

@@IE5441
I have SIBO and leaky gut and I am interested to see where you are going with this. I haven't had the test but I have a slow system and my colon and ileocecal valve was removed. Also just stopped 8 months of antibiotics for mycoplasma infection. So, a couple of significant risk factors and a list of symptoms.
Testing showed antibodies to all dairy and eggs and that leaves me with veggies, oil and meat/fish. I can have fruit but am not drawn to it. I have to tackle this and I am starting with Humaworm. Thought I would clear the big boys from the field.
Since the antibiotics my gut has gotten worse - multiple skin problems and histamine in overdrive.
The good news is that I am down to one mB12 injection daily and absorbing folate better.

Gut bacteria make b12. Unfortunately not usable. Do you have sibo?

Thanks @@IK7484! That's great info and fits into what I've been hearing from others. My naturopathic doctor also agrees that I'm B12 deficient. The mystery for me is that my MMA test was completely normal. This test seems to be the main test for B12 deficiency other than blood serum (I have not done a Spectracell test). I did take a NutrEval Genomics test that showed I was "borderline" deficient in all B vitamins, including B12, even after months of supplementing with methylcobalamin. My homocysteine is low (around 4.5) and I've got macrocytosis (enlarged blood cells). It's not clear to me how NutrEval measures vitamin levels and I'm still in the dark about how is B12 deficiency would be determined/measured in my case especially given normal MMA and daily supplementing. Any light you can shed would be great!

High serum B12 levels are even more common in people with the Fut2 gene. I also have it and have researched it quite a bit on SNPedia. We're just showing the vitamin intake from a supplement or food, but we aren't converting it to the active form. cyanocobalamin still has to be metabolized into Methylcobalamin by your body. Fut2 folks are unable to make this conversion step. That being said, the high levels of B12 in your blood are probably just a lot of "inactive B12" that you're body can't even use. Sublingual Methylcobalamin would be your first step. Some people have to just take B12 shots if the sublingual isn't working. I'm also in the medical industry so have been educated quite a bit by functional Medicine docs. Good luck! I hope you feel better!

The level of B12 in the blood is false indication for B12 deficiency or adequecy. You may check with Methylmalonic Acid MMA
Check with Genes mainly MUT and MMAA, MMAB