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I am seeing a genetics MD now. She is testing me for mitochondrial DNA issue due to long standing fatigue issues in me and other family members. I will find out the results in a few weeks.

I am seeing a genetics MD now. She is testing me for mitochondrial DNA issue due to long standing fatigue issues in me and other family members. I will find out the results in a few weeks.

My genotype for DIO1 rs2235544 is AA. I have many symptoms of low thyroid, my mom has been on thyroid supplements for 50 years and my sister has Hashimoto's thyroiditis. My labs of all of the thyroid tests here are all in the "normal' range but all of us have overweight issues, and fatigue, etc. I will review my results in reference to @VE6992's suggestions.

Does anyone know where to get a consult in Maryland? This is so confusing but exciting that I may figure out what is going on with me.

Thanks for everyone who contributes their knowledge and insights here.

Please look into your microbiome as well.
Www.SevenStreamsToWellness.com

Your swelling is most likely inflammation and edema. The inflammation and edema could be coming from another problem, but it could exacerbate your thyroid issue. Some people have great success in addressing thyroid issues by eliminating wheat, barley, rye, and all dairy except for butter, and other foods. You might learn more by going to the Paleo Mom website and seeking thyroid information. The person on the site is a PhD with a lot of personal experience with problems that led her away from her career plans to become a physician. Just reading about how she went about discovering the source of her very serious problem is fascinating. She went on to become an expert. The Autoimmune Protocol is on this page. https://www.thepaleomom.com/start-here/the-autoimmune-protocol/. Go there, bookmark it for later reference, then search thyroid. Having the gene is one thing. Environmental factors may play in a role in whether or not it is expressed, and the extent of the expression.

@VD7457,
Please do your research as ZQ recommended. Post thyroid cancer, I have fired endocrinologists and I refuse to ever see another one. In my world:
ENDO = Everything Not Done Optimally!
It was my first endo who made me VERY ill and his answer to everything was see a specialist! I hit my ins catastrophic cap 2 years in a row thanks to all the specialists and tests. Found nada.

My illness was all do to the DIO1 & DIO2 mutations. With those mutations, you cannot do synthroid.
Please do not put the drs in charge of your health. You already feel crummy enough and are mudding out on life.
Do your due diligence and STUDY and LEARN from what we shared with you. Sadly, no dr is going to give you your health back when it comes to hypothyroidism. Hundreds of thousands of us all over the world found out the hard way.
Many of us order our own labwork and rx's overseas. We have worked it butts off ( ) to get our lives back and we are back to the land of living, new and improved!
It's going to be all up to you.
Good luck!

I hope this response finds you both well. I am very new at trying to read my data. I will respond to how I found the mutation under variants on my report, I went in and googled different variant homo and heterozygous to see what they all meant. To be completely honest I wasn't sure it was accurate until the cy282y showed up and I knew for sure I am an asymptomatic heyerozygous carrier of this gene. So then I went back and began reviewing all of my variants. I have been having this issue with my weight since I had my second child. I am a very active person that consumes very little food, so not losing weight is very frustrating to me, however I can even cope with being fluffy if I wasn't so tired and drained with aching shoulder and neck. My doctor always wants to do a new diet but I told him I have been on a perpetual diet for 9 years and I am more interested in why I feel like crap rather than chunking pills at it. I am looking through my lab and he did a comprehensive metabolic panel but ... More

I hope this response finds you both well. I am very new at trying to read my data. I will respond to how I found the mutation under variants on my report, I went in and googled different variant homo and heterozygous to see what they all meant. To be completely honest I wasn't sure it was accurate until the cy282y showed up and I knew for sure I am an asymptomatic heyerozygous carrier of this gene. So then I went back and began reviewing all of my variants. I have been having this issue with my weight since I had my second child. I am a very active person that consumes very little food, so not losing weight is very frustrating to me, however I can even cope with being fluffy if I wasn't so tired and drained with aching shoulder and neck. My doctor always wants to do a new diet but I told him I have been on a perpetual diet for 9 years and I am more interested in why I feel like crap rather than chunking pills at it. I am looking through my lab and he did a comprehensive metabolic panel but did not screen for the free t3, t4 or reverse. I am hoping to have an endo. Sort this out. I am tired of having an active heart full of energy and adventure with a body that betrays my goals. I will ask my endo specifically for these tests. Thank you for your time to comment! Less

Totally agree with the ZQ's comment below. And very few drs, let alone endos understand the thyroid let alone do the proper bloodwork or interept them correctly. Free t4, Free t3, AND REVERSE T3 are crucial!
The DIO1 & DIO2 SNPs (among others) refer to your body's ability to convert the STORAGE thyroid hormone (T4) into the ACTIVE thyroid hormones (T3, T2, and T1) that do all the work in your body. Currently there are no tests for free t2 or free t1.
Having mutated DIO2 and DIO1 SNPS means you do NOT convert the T4 storage hormone into the usable thyroid hormones. That leaves you with all sorts of hypothyroid symptoms. Commonly the weight issues you referred to. If you check hypothyroidism you'll find plenty more symptoms you will have now or in the future.
Wish I could say changing your diet solves it. It helps but you need the Right thyroid hormones in the cells to solve it. Most of us find no grains or dairy HELPS immensely as well as high quality selenium and zinc to help the T4 conversion into T3 but that does not solve the thyroid hormones shortage issue. With hashimotos disease ... More

Totally agree with the ZQ's comment below. And very few drs, let alone endos understand the thyroid let alone do the proper bloodwork or interept them correctly. Free t4, Free t3, AND REVERSE T3 are crucial!
The DIO1 & DIO2 SNPs (among others) refer to your body's ability to convert the STORAGE thyroid hormone (T4) into the ACTIVE thyroid hormones (T3, T2, and T1) that do all the work in your body. Currently there are no tests for free t2 or free t1.
Having mutated DIO2 and DIO1 SNPS means you do NOT convert the T4 storage hormone into the usable thyroid hormones. That leaves you with all sorts of hypothyroid symptoms. Commonly the weight issues you referred to. If you check hypothyroidism you'll find plenty more symptoms you will have now or in the future.
Wish I could say changing your diet solves it. It helps but you need the Right thyroid hormones in the cells to solve it. Most of us find no grains or dairy HELPS immensely as well as high quality selenium and zinc to help the T4 conversion into T3 but that does not solve the thyroid hormones shortage issue. With hashimotos disease you will also have thyroid antibodies, however 20% of us with hashimotos never develop antibodies. That's me.
Untreated hypothyroidism leads to an increased chance of thyroid cancer. Also me.

Think of your body as a car... it needs gas to run. T4 thyroid hormone is your gas, in raw form and unusable. It must be broken down (deiodinasing is the breaking down thyyoid hormones into usable forms by losing or converting an iodine atom..) Once the raw gas is broken down and refined into pumping gasoline it is usable. That is the gas for your body and makes it work.
Once you have the proper amounts of thyroid hormones in your blood stream to do the jobs properly, you are only halfway there. Your body needs to get it INTO YOUR CELLS to work, not just floating around in your blood. Each of your body's cells have receptors on them for free t3 to enter.

This is where Reverse t3 comes in. Reverse t3 BLOCKS free t3 (usable hormone) from entering your cells.
T4 meds convert into free t3 OR Reverse t3

With the DIO1 & DIO2 mutations, your body makes high reverse t3 out of t4 meds. Blocking your cells from getting any of the much needed t3!

Sadly, most drs are clueless about reverse t3 and big pharma runs their medical schools so they are taught the gold standard thyroid hormone replacement is t4 meds such as Synthroid, Levoxyl, Tirosint, or generic Levothyroxine. A few of them recognize Cytomel which is a synthetic T3 hormone replacement. Most of them have been taught Natural Dessicated Thyroid (NDT) is old fashioned, not reliable, or in the patients best interest. Which is BS. Big pharma's cash cow are the T4 meds and they cannot patent NDT or make much money off it so it's not taught to drs. And you certainly cannot rely on the standard TSH test when taking ndt or cytomel. The TSH test is a Thyrpid Stimulating Hormone which is a messenger hormone from the pituitary gland to tell the thyroid make more hormones. It's not even a thyroid hormone but drs believe that only doing a TSH test is sufficient. Then they misread results or worse, fail to do the right tests leaving you very sick making you sicker.

The lab range results the dr looks at are skewed. Lab companies use a random group of people and their results creating the lab ranges of high and low. The problem is they INCLUDES sick hypothyroid people!! That's not the right tool when seekimg optimal health!!
A health tnyroid situation should show a low tsh no more than 1.5 of the thyroid is overworking.
A free t3 in the upper end
A reverse t3 less than 15
And free t4 should be mid to low range.
Zinc, Selenium, a clean diet, and LDN help lower antibodies.

Stop the thyroid madness is a good place to start but no dr will listen if you ever say you are reading sttm books. Your best bet to help you dr understand is to read Dr Kent Holtorf's site National Academy of Hypothyroidism. Also Dr Jeffrey Dach's website and extensive documented research. Doctors may listen to other drs... that is a whole other topic itself!
Study for yourself, knowledge is power.
Practical application is optimal health!
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Hi, where did you find this snp on the report - I ask because I've looked and can't find it.
If you have a thyroid disorder you will need to be well read. For a good place to start is the site and book stop the thyroid madness. You will need to have the full range of thyroid bloods taken. This includes free T3 and antibodies. You want your results to be optimal not just in range FT3 especially needs to be high in the range.